Ramos, Raddy L Van Dine, Sarah E Gilbert, Mary E Leheste, Joerg R Torres, German Neurodevelopmental Malformations of the Cerebellar Vermis in Genetically Engineered Rats. Measurements of cerebellar vermis may provide a quantitative index for prenatal diagnosis of posterior fossa malformations. The 3D approach may enable rapid assessment of fetal cerebral anatomy in standard examination. Three-dimensional median planes are obtained more easily than two-dimensional ones, and allow accurate measurements of the cerebellar vermis. The normal vermis was almost parallel to the brain stem, with the average angle degree to be 5°. The diameter of the cerebellar vermis follows growth approximately predicted by the quadratic regression equation. Measurements of the cerebellar vermis were highly correlated between two-dimensional and 3D median planes. 3D median planes were obtained with both OMNIVIEW and tomographic ultrasound imaging. Sonographic examinations were performed in normal fetuses and in cases suspected of the diagnosis of vermian rotation. The purpose of this study was to investigate the effectiveness for quantitative evaluation of cerebellar vermis using three-dimensional (3D) ultrasound and to establish a nomogram for Chinese fetal vermis measurements during gestation. Zhao, Dan Liu, Wei Cai, Ailu Li, Jingyu Chen, Lizhu Wang, Bing Quantitative evaluation of the fetal cerebellar vermis using the median view on three-dimensional ultrasound. Sprague-Dawley, and Long-Evans rats exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the vermis. The cerebellar vermis is particularly vulnerable to neurodevelopmental malformations in humans and rodents. Neurodevelopmental malformations of the cerebellar vermis in genetically engineered rats Follow-up imaging at a later gestational age is crucial to ensure that this condition is not over-reported and to avoid the potential risk of unnecessary pregnancy interruption. Embryologically, delayed permeabilization of Blake's pouch could account for the delayed vermian rotation. Incomplete rotation of the cerebellar vermis can be a physiological finding on early second-trimester fetal MRI examination and can simulate DWM or other forms of cerebellar hypoplasia. Both children had normal psychomotor development and neurological examinations at 1 year of age. Follow-up MRI at 28 + 3 weeks' gestation (Case 1) and at 1 postnatal year (Case 2) showed completely normal findings. The posterior fossa appeared to be mildly enlarged, while all other findings were normal. In both cases, upward rotation of the cerebellar vermis was noted on midsagittal imaging, the brainstem- vermis angle was 28° and 43°, respectively, while cerebellar morphometry showed a reduced vermian anteroposterior diameter compared to reference data. Two pregnant women with suspected fetal posterior fossa anomaly on ultrasound examination underwent fetal MRI at 21 (Case 1) and 19 (Case 2) weeks' gestation. We describe two cases in which delayed rotation of the cerebellar vermis simulated a Dandy-Walker malformation (DWM) on early second-trimester magnetic resonance imaging (MRI). Pinto, J Paladini, D Severino, M Morana, G Pais, R Martinetti, C Rossi, A Delayed rotation of the cerebellar vermis: a pitfall in early second-trimester fetal magnetic resonance imaging.
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